After finishing his studies in Belgrade, in 1941 he returns to Prilep, where, as a member of KPJ (the Communist Party of Yugoslavia), on October 11 he takes part in the attack of the police station of the city. He is arrested.
After the breaking of the Prilep partisan force, Casule comes to Skopje where he takes part in a lot of KP actions. He is found by the Bulgarian police and arrested. After two years in prison he escapes and is again a part of the NOV (the army fighting for national freedom during the WW2).
Kole Casule is a narrator and playwriter. Some of his more famous plays include: Vejka na vetrot, Crnila, Vitel etc.
Casule has won a lot of prizes for his literary activities, among which is the prize '11-th of October'.